Jacksonville Jaguars at Baltimore Ravens, 1 p.m., CBS
Line: Ravens -14 | Total: 47.5
There were so many jokes. Lamar Jackson engineered one of the wildest wins in recent N.F.L. history, completing a 44-yard touchdown to Marquise Brown on fourth-and-5 with less than two minutes left in the game, then watching Cleveland tie the score, and then taking the Ravens far enough for Justin Tucker to kick a game-winning, 55-yard field goal. But all anyone wanted to talk about was Jackson’s brief absence and how it looked as if he might have taken a bathroom break.
Laugh all you want — Jackson swears he was receiving fluids to alleviate cramping — but the win was a welcome change in what had been a difficult period for the Ravens (8-5). Jackson finally looked like himself, and the Ravens, with a 74 percent chance of making the playoffs, no longer seemed like a team in peril.
This game does not figure to be nearly as entertaining. The Jaguars (1-12) haven’t won a game since Week 1, and struggle on both sides of the ball. Having Baltimore as a two-touchdown favorite when you consider the team’s recent defensive struggles seems like a bit too much. Pick: Jaguars +14
Houston Texans at Indianapolis Colts, 1 p.m., CBS
Line: Colts -7 | Total: 52.5
In most years, this would be a key A.F.C. South matchup, but the Texans (4-9) have been eliminated from playoff contention and the Colts (9-4) have an 82 percent chance of making the playoffs and a 36 percent chance of winning their division. Houston’s Deshaun Watson will be the best player on the field, but the Texans have done a shameful job of keeping talent around him. Indianapolis, on the other hand, made crucial personnel moves in the off-season that have taken the team from mediocre to top 10 in offense and defense. Pick: Colts -7
Detroit Lions at Tennessee Titans, 1 p.m., CBS
Line: Titans -10.5 | Total: 51.5
There are situations in which the Lions (5-8) could hold their own against the Titans (9-4), but most of them involve locking Tennessee’s Derrick Henry in a well-guarded room and insisting nobody knows where he is. Barring high jinks, Detroit seems remarkably overmatched, especially if Matthew Stafford misses the game with the rib injury he sustained last week. Tennessee is in a tough fight with Indianapolis for the A.F.C. South crown, and has a 64 percent chance of holding off the Colts, so the Titans certainly have motivation to keep winning. Pick: Titans -10.5
Chicago Bears at Minnesota Vikings, 1 p.m., Fox
Line: Vikings -3 | Total: 46
Both teams are on the outside looking in, but the Bears (6-7) and the Vikings (6-7) are still alive, and both have at least a 20 percent chance of a playoff spot despite Chicago’s recent struggles and Minnesota’s rough start. Assuming the Bears’ offensive resurgence last week was more than a blip would probably be generous, but they certainly have looked their best with Mitchell Trubisky at quarterback. Even accounting for that, Minnesota should be fine, provided the team gives quarterback Kirk Cousins more time to work than he had in a loss to Tampa Bay. Pick: Vikings -3